Ppremature infants with respiratory distress syndrome
Conditions
Interventions
Experimental group:weaning from high-frequency oscillatory ventilation directly
control group:switching and subsequent weaning and extubating from conventional mechanical ventilation
Sponsors
Xiamen Maternal and Child Care Hospital, Women and Children's Hospital, School of Medicine, Xiamen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Children diagnosed with NRDS; 2. Premature infants with GA <= 32 + 6 weeks or BW <= 1500g; 3. Infants born in our hospital should be admitted within 2 hours after birth; 4. HFOV is the first choice and mechanical ventilation is more than 24 hours.
Exclusion criteria
Exclusion criteria: 1. Children with congenital malformations; 2. The subjects of genetic metabolic diseases; 3. The subjects of grade 3-4 intracranial hemorrhage; 4. Children whose family members do not agree to use HFOV or PS; 5. Family members give up treatment or the child dies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| reintubation rate after 72 hours of ventilator withdrawal;invasive mechanical ventilation time;total mechanical ventilation time;total oxygen consumption time;the level of partial pressure of carbon dioxide (PaCO2) after 2 hours when extubated from HFOV; | — |
Secondary
| Measure | Time frame |
|---|---|
| the incidence rate of bronchopulmonary dysplasia;the incidence rate of intraventricular hemorrhage;the incidence rate of periventricular leukomalacia;the incidence rate of ventilator associated pneumonia;the incidence of air leakage syndrome;the incidence of retinopathy of prematurity;hospitalization time; | — |
Countries
China
Contacts
Public ContactLin Xinzhu
Xiamen Maternal and Child Care Hospital, Women and Children's Hospital, School of Medicine, Xiamen University
Outcome results
None listed