Skip to content

Applicaiton of sulphur hexafluoride microbubbles in the diagnosis of renal allograft blood flow disorders and acute rejection in recipients of kidney transplants

Applicaiton of sulphur hexafluoride microbubbles in the diagnosis of renal allograft blood flow disorders and acute rejection in recipients of kidney transplants

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000038263
Enrollment
Unknown
Registered
2020-09-15
Start date
2020-11-01
Completion date
Unknown
Last updated
2020-12-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal transplantation

Interventions

Gold Standard:1. Ultrasound diagnostic criteria for renal artery stenosis. 2. The diagnostic criteria of renal artery occlusion. 3. Semi-quantitative classification of renal perfusion. 4. Acute reject
Index test:1.&#32
blood&#32
flow&#32
(RBF) 2.&#32
index&#32
(RI)&#32
and&#32
pulsatility&#32
(PI) 3.&#32
rising&#32
of&#32
contrast-enhanced&#32
ultrasound&#32
(A1),&#32

Sponsors

The Affiliated Hospital Of Guizhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 69 Years

Inclusion criteria

Inclusion criteria: 1. The Patients after kidney transplantations, who are 18-69 years old; 2. The level of serum creatinine progressively increases > 50umol/L within two weeks; 3. Exclude CMV, BK, EB and other viral infections, as well as other pathogenic lung infections, urinary tract infections and other factors that cause the level of serum creatinine to be increased; 4. Exclude the patients who have contraindications of Contrast-enhanced ultrasound.

Exclusion criteria

Exclusion criteria: 1. The patients who have allergic history of ultrasound contrast agents. 2. The patients who have heart disease with right-to-left shunt, with severe pulmonary hypertension (pulmonary artery pressure> 90 mmHg), with uncontrolled hypertension and acute respiratory distress syndrome. 3. Pregnant women, lactating women, and minors under 18 years old. 4. It is contraindicated in patients with recent acute coronary syndrome or clinically unstable ischemic heart disease: acute heart failure, heart failure grade III/IV and severe heart rhythm disorders. 5. Those patients who are treated by extracorporeal shock wave treatment(before and after treatment within 24h.)

Design outcomes

Primary

MeasureTime frame
Cr;SEN, SPE, ACC, AUC of ROC;

Countries

China

Contacts

Public ContactYuan Xu

The Affiliated Hospital Of Guizhou Medical University

xuyuan@gmc.edu.cn+86 13312267131

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026