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The lowest effective dose of norepinephrine infusion for preventing postspinal hypotension during elective cesarean section: a comparative study of single and twin pregnancy

Norepinephrine infusion for preventing postspinal hypotension during elective cesarean section in single and twin pregnancy: a randomized, double-blind, dose-effect study

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000038261
Enrollment
Unknown
Registered
2020-09-15
Start date
2020-11-01
Completion date
Unknown
Last updated
2020-12-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypotension

Interventions

Group S1:Norepinephrine infusion at a rate of 0.025ug /kg/min
Group S2:Norepinephrine infusion at a rate of 0.05ug /kg/min
Group S3?:Norepinephrine infusion at rate of 0.075ug /kg/min
Group S4:Norepinephrine infusion at a rate of 0.1ug /kg/min
Group S5:Norepinephrine infusion at rate of 0.125ug /kg/min
Group T1:Norepinephrine infusion at rate of 0.025ug /kg/min
Group T2:Norepinephrine infusion at rate of 0.05ug /kg/min
Group T3:Norepinephrine infusion at rate of 0.075ug /kg/min
Group T4:Norepinephrine infusion at rate of 0.01ug /kg/min
Group T5?:Norepinephrine infusion at a rate of 0.125ug /kg/min

Sponsors

West China Second Hospital of Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 35 Years

Inclusion criteria

Inclusion criteria: Full-term, singleton pregnant women and parturients of twin pregnancy with a gestational age greater than 32 weeks scheduled for elective cesarean delivery were enrolled in the study.

Exclusion criteria

Exclusion criteria: 1. The maternal has serious cardiovascular and cerebrovascular diseases; 2. Pregnancy induced hypertension, diabetes mellitus, known fetal abnormalities; 3. Patients with contraindications to spinal anesthesia were excluded from the study. 4. Patients younger than 20 years old or older than 35 years old are also included; 5. Patients with high or low height ( 180cm); 5. Patients with BMI > 30 kg / m2 and ASA grade >= 3; 6. Parturients with single gestational age less than 36 weeks and systolic blood pressure < 100 mmHg.

Design outcomes

Primary

MeasureTime frame
Blood pressure;

Countries

China

Contacts

Public ContactHuang Han

West China Second Hospital of Sichuan University

han.huang@scu.edu.cn+86 13880259786

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026