Severe infection
Conditions
Interventions
Intervention group:Each patient was given a loading dose of 10-12mg / kg q12h * 3-5. The concentration of teicoplanin half an hour before the fourth dose and at the maintenance dose was determined. Th
Control group:Teicoplanin is recommended to be administered at a loading dose of 6mg / kg * 3 doses and a maintenance dose of 6mg / kg, QOD. The teicoplanin Valley concentration was measured half an h
Sponsors
Suzhou Municipal Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Patients who need to use teicoplanin empirically or targeted anti infective therapy according to the clinical infectious disease and severity; 2. Patients with acute renal failure caused by critical illness; 3. Patients with oliguria or anuria during CRRT; 4. Patients older than 18 years old.
Exclusion criteria
Exclusion criteria: 1. Subjects with urine volume > 0.5ml/kg/h during CRRT; 2. Patients undergoing extracorporeal membrane oxygenation; 3. Patients with other non acute renal injury who underwent CRRT; 4. Subjects allergic to teicoplanin or with serious adverse reactions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The trough concentration;the plasma concentration;Filtrate concentration;CRRT parameters; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pathogen culture;leukocyte;Procalcitonin;C-reactive protein;Body Temperature;Albumin;APACHE II Score;Adverse reactions;Kidney function indicators;Liver function index;Other nephrotoxic drugs and combination drugs;Age;Gender;Height;Weight;Diagnosis and complications; | — |
Countries
China
Contacts
Public ContactTang Lian
Suzhou Municipal Hospital
Outcome results
None listed