Pediatric tumors
Conditions
Interventions
Trial group:PEG-rhG-CSF
Sponsors
Sun Yat-Sen University Cancer Center
Eligibility
Sex/Gender
All
Age
6 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. The patients with 6-18 years old had no gender limitation; 2. Tumor patients diagnosed by histopathology or bone marrow cytology; 3. The patients were evaluated by scccg regimen; 4. Patients with ECoG score = 1.5 x 10^9 / L, PLT >= 80 x 10^9 / L, Hb >= 75 g / L, WBC >= 3.0 x 10^9 / L); 7. Patients receiving high-intensity chemotherapy, such as scccg lymphoma regimen, CAV / ie, VIP regimen, etc., are expected to have grade III bone marrow suppression after chemotherapy. 8. The legal guardian of the subjects must sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with local or systemic infection without adequate control; 2. Patients with severe visceral dysfunction; 3. Liver function test: total bilirubin (TBIL), alanine aminotransferase (ALT), aspartate aminotransferase (AST) were more than 2.5 times of the upper limit of normal value, if due to liver metastasis, the above indicators were more than 5 times of the upper limit of normal value; renal function test: serum creatinine (CR) > 2 times of the upper limit of normal value; 4. Patients who took the same kind of other tested drugs or accepted other clinical trials within 4 weeks before enrollment; 5. Patients who are allergic to peg rhG CSF, rhG CSF and other preparations or proteins expressed by Escherichia coli; 6. Patients with severe mental illness, which affect informed consent and / or adverse reaction expression or observation; 7. The researcher judged the patients who were not suitable to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the safety of PEG-rhG-CSF in the prevention of neutropenia in children with tumor after chemotherapy.;To evaluate the effectiveness of PEG-rhG-CSF in preventing neutropenia in children with tumor after chemotherapy.; | — |
Countries
China
Contacts
Public ContactYizhuo Zhang
Sun Yat-Sen University Cancer Center
Outcome results
None listed