Total knee arthroplasty
Conditions
Interventions
Group 1:TXA 0.5 g
Group 2:TXA 1g
Group 3:TXA 2g
Group 4:TXA 3g
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Undergo unilateral TKA for knee osteoarthritis were recruited. TKAs were generally performed to the patients who had degeneration change of Kellgren and Lawrence grade 3 or 4 on X-ray with persisting pain without response to conservative treatment such as drugs or intraarticular injection.
Exclusion criteria
Exclusion criteria: The exclusion criteria were preoperative anemia (hemoglobin level 1.4, or prolonged partial thromboplastin time [> 1.4 times normal]), acquired disturbances of color vision, history of arterial or venous thromboembolic disease (such as a cerebrovascular attack, DVT, or PE), and major comorbidities (including previous myocardial infarction, heart failure, pulmonary disease and renal or hepatic failure). Patients who had not received spinal anesthesia, those with medical complications during anesthesia, surgical complications, such as intraoperative fracture or inevitable use of revision implant, or postoperative management complications, such as non-functional Hemovac drain, were excluded from the study.
Countries
China
Contacts
Public ContactFeng Shuo
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed