Unilateral hip or knee replacement
Conditions
Interventions
experimental group:Goal-directed fluid therapy combined with norepinephrine
control group:Conventional infusion
Sponsors
University-Town Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with age >= 60 years who are proposed to undergo single hip or knee replacement under general anesthesia; Preoperative ASA class I - III; 2. 18 kg/m2 or less BMI 25 kg/m2 or less; 3. Patients with informed consent can cooperate with process implementation.
Exclusion criteria
Exclusion criteria: 1. There was severe liver and kidney dysfunction before operation (liver enzyme was 3 times higher than the upper limit of normal value, Cr or BUN was higher than the upper limit of normal value); 2. Serious cardiovascular disease, cardiac insufficiency NYHA III level or higher, unstable angina, heart failure, etc.); 3. Severe bradycardia (heart rate less than 50 beats/min), severe arrhythmias (such as ventricular fibrillation, atrial fibrillation, frequent ventricular premature beats, frequent atrial premature beats, etc.), severe conduction block, peripheral vascular diseases; 4. Preoperative history of thromboembolism; 5. Preoperative HCT <= 30%, Hb < 100g/L; 6. The presence of mental illness before surgery; 7. Hearing impairment, difficulty in language communication; 8. Allergic to the drugs used in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arterial blood gas analysis;Venous blood gas analysis;Blood pressure;Heart rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total amount of input liquid; | — |
Countries
China
Contacts
Public ContactYao Yuting
University-Town Hospital of Chongqing Medical University
Outcome results
None listed