Chronic Atrophic Gastritis
Conditions
Sponsors
Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged from 18 to 70 years old, regardless of gender; 2. Patients who meet the diagnostic criteria of chronic atrophic gastritis and are negative for Helicobacter pylori (at least one 13C or 14C breath test is required); 3. The pathology belongs to Olga stage II and stage III. Two experts from the pathology department were required to make the diagnosis (pathological reading) of the patients, and the two experts had the same opinion; 4. Patients who voluntarily participate in this clinical trial should give informed consent and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with peptic ulcer, severe dysplasia of gastric mucosa (high grade intraepithelial neoplasia) or suspected malignant lesions by pathological diagnosis; 2. Patients with severe digestive system diseases or history of abdominal surgery; 3. Pregnant and lactating women; 4. Patients with severe heart, lung, hematopoietic system, malignant tumor and other primary diseases, severe diabetes mellitus, chronic liver and kidney dysfunction, in which ALT of liver function damage is more than 1.5 times of the upper limit of normal value, and serum creatinine (CR) of renal function damage is 1.5 times of the upper limit of normal value; 5. The patients whose platelets were lower than 1.5 times of the lower limit of normal value; 6. Patients with disabilities prescribed by law (blindness, deafness, dumb, mental retardation, mental disorder and physical disability); 7. Patients with history of alcoholism; 8. Patients with allergic constitution or history of allergy to multiple drugs (more than two or known ingredients in the drug); 9. Patients who have participated in clinical trials of other drugs in the past 4 weeks; or those who have used preparations such as Weifuchun, morodan and folic acid in the past 2 weeks; and; 10. According to the researcher's judgment, it is easy to lose the interview or other reasons that are not suitable for selection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastroscopy and Gastric mucosal biopcy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Indigestion symptom checklist;12-item short-form health survey, SF-12; | — |
Countries
China
Contacts
Public ContactLing Jianghong
Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine
Outcome results
None listed