Acute myocardial infarction
Conditions
Interventions
experimental group:Sequential intravenous injection of esmolol immediately after treatment with metoprolol tablets
control group:metoprolol tablets
Sponsors
Pingdingshan First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of the guidelines for the management of acute myocardial infarction (except inferior myocardial infarction); 2. Heart function classification I or II (Killip classification); 3. Age over 18 years old; 4. There are no contraindications for the drugs in this study; 5. Within 12 hours of onset; 6. Families and patients informed consent to this study.
Exclusion criteria
Exclusion criteria: 1. Bronchial asthma or a history of bronchial asthma; 2. Severe chronic obstructive pulmonary disease; 3. Sinus bradycardia (less than 50 beats/min); 4. PR interval> 0.24s, second to third degree atrioventricular block; 5. Heart failure or low cardiac output or refractory cardiac insufficiency; 6. Cardiogenic shock or high-risk patients (age>70 years old, systolic blood pressure 110 beats/min); 7. Combined with congenital heart disease and valvular heart disease; 8. After coronary artery bypass grafting; 9. Severe liver and kidney dysfunction, acute and chronic infections and malignant tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of major adverse cardiovascular events;All-cause mortality; | — |
Countries
China
Contacts
Public ContactTiexun Zhang
Pingdingshan First People's Hospital
Outcome results
None listed