Sedation in severe patients
Conditions
Interventions
Experimental group:Sedate with Remazolam Benzenesulfonate
Control group:Sedate with midazolam
Sponsors
Xinyang central hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Age >= 18 years old and <= 75 years old; 2) All patients who need sedation in ICU; 3) Obtain informed consent of patients or their families.
Exclusion criteria
Exclusion criteria: 1) Pregnancy or breastfeeding; 2) Those who need general anesthesia surgery within 48 hours; 3) Severe and existing parenchymal liver diseases with clinically significant portal hypertension, Child-Pugh grade C cirrhosis or acute liver failure; 4) Patients with acute and chronic renal insufficiency who need dialysis treatment; 5) Severe craniocerebral injury, brain tumor, increased intracranial pressure, cerebrovascular accident, coma, status epilepticus, etc.; 6) Patients with a history of alcohol or drug abuse; 7) Unable to obtain informed consent or authorization; 8) Participate in other exploratory clinical trials within 6 months before screening; 9) Known or suspected allergy to Remazolam, midazolam, propofol, dexmedetomidine and opioids.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation score;Vital signs; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hospitalization time in ICU;Mechanical ventilation time; | — |
Countries
China
Contacts
Public ContactLu Yibin
Xinyang central hospital
Outcome results
None listed