The effect and mechanisms of environmental polycyclic aromatic hydrocarbons exposure on occurrence and development of systemic lupus erythematosus

The effect and mechanisms of polycyclic aromatic hydrocarbons exposure on occurrence and development of systemic lupus erythematosus, focusing on the aryl hydrocarbon receptor pathway

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2000038187

Enrollment

Unknown

Registered

2020-09-12

Start date

2020-09-21

Completion date

Unknown

Last updated

2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Systemic lupus erythematosus

Interventions

systemic lupus erythematosus group:Nil

Healthy control group:Nil

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. The case group: >= 18 years old; Meets at least one of the classification criteria for SLE, 1997 American College of Rheumatology (ACR97) and/or 2012 Systemic Lupus International Collaborating Clinics (SLICC12)Dose not have chronic infectious diseases (such as hepatitis B, tuberculosis, etc.) and is not in a state of acute infection (such as upper respiratory tract infection). 2. The control group: Healthy people matched with age and sex of patients in the case group; Dose not have chronic infectious diseases (such as hepatitis B, tuberculosis, etc.) and is not in a state of acute infection (such as upper respiratory tract infection)..

Exclusion criteria

Exclusion criteria: 1. Does not agree to participate in this study during the informed consent process; 2. There are neurological, mental illness or physical disorders (such as deaf-mute) that may affect environmental exposure assessment.

Design outcomes

Primary

Measure	Time frame
Polycyclic aromatic hydrocarbons-albumin adducts;Systemic lupus erythematosus disease activity;Contents of 16 common polycyclic aromatic hydrocarbons in serum;Contents of 12 polycyclic aromatic hydrocarbon metabolites in urine;Expression of AhR and Cyp1a1 in different T cell subsets;	—

Secondary

Measure	Time frame
IFI44L promoter methylation level;Overall methylation level of whole blood DNA genome;	—

Countries

China

Contacts

Public ContactQianjin Lu

The Second Xiangya Hospital of Central South University

qianlu5860@gmail.com+86 13797097676

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 8, 2026