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To explore the essence of DOR kidney-yang deficiency syndrome and the intervention mechanism of Yangluanfang decoction based on follicular fluid metabolomics

To explore the essence of DOR kidney-yang deficiency syndrome and the intervention mechanism of Wenshenyangluanfang decoction based on follicular fluid metabolomics

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000038182
Enrollment
Unknown
Registered
2020-09-12
Start date
2020-10-01
Completion date
Unknown
Last updated
2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Decreased ovarian reserve

Interventions

Sponsors

Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: The inclusion criteria of the observation group were as follows: 1. Married female patients aged 20 ~ 40 years old, Those with fertility requirements; 2. Meet the diagnostic criteria for infertility due to decreased ovarian reserve function, and TCM syndrome differentiation belongs to kidney-yang deficiency; 3. No obvious abnormality was found in the sperm examination of the male; 4. Volunteer to participate in this study and sign the informed consent, can actively cooperate with the follow-up, complete the clinical observer. The inclusion criteria of the control group were as follows: 1. Married female patients aged 20 ~ 40 years old, those with fertility requirements; 2. In line with the diagnostic criteria of tubal obstructive infertility; 3. In line with the standard of normal ovarian reserve function; 4. No obvious abnormalities were found in the sperm examination of the man; 5. Voluntarily participate in this study and sign the informed consent, actively cooperate with the follow-up visits and complete the clinical observation.

Exclusion criteria

Exclusion criteria: 1. Those with previous mental illness or allergic constitution; 2. Previous history of various malignant tumors, cardiovascular and cerebrovascular disease, abnormal liver and kidney function, or hematopoietic system and other serious primary diseases; 3. Men with abnormal reproductive functions; 4. Women with polycystic ovary syndrome, immune factors, endometriosis and other infertility factors; 5. Organic lesions or congenital physiological defects or malformations of the reproductive system; 6. Long-term application of exogenous hormone therapy for patients.

Design outcomes

Primary

MeasureTime frame
Serum follicle-stimulating hormone;Serum luteinizing hormone;Serum estradiol;Serum progesterone;Serum anti-Mullerian hormone;Sinus follicle count;

Secondary

MeasureTime frame
Syndrome integral of kidney-Yang deficiency;The oocyte count was obtained;Fertilization rate;Grade III oocyte rate;High quality embryo rate;

Countries

China

Contacts

Public ContactXiaole Zhang

Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine

zhangxiaole515@163.com+86 13512188016

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 21, 2026