lumbar degenerative disease
Conditions
Interventions
Group A:saline 30 min preoperative iv.
Group B:Tranexamic acid: 20mg/kg preoperative iv.
group C:Tranexamic acid (20mg/kg 30min preoperative + 10mg/kg 3h after surgery)
Sponsors
Department of Orthopedics, West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients Diagnosed with lumbar degenerative diseases,such as lumbar disc herniation, lumbar canal stenosis and lumbar spondylolisthesis,and with indications for posterior lumbar fusion surgery. 2. Patients should Perform primary lumbar fusion , with operative level limited to 1 or 2 segments. 3. Preoperative Hb were normal; No abnormality was found in the color doppler ultrasound of the veins of both lower extremities. 4. Above the age of 40 years old.
Exclusion criteria
Exclusion criteria: 1. Coagulation and fibrinolysin disorders; 2. History of lumbar surgery, multilevel surgery; 3. Allergic to tranexamic acid.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood loss (total blood loss, hidden blood loss, intraoperative blood loss, postoperative blood loss);Blood transfusion rate;volume of drainage (1d, 2d and 3d postoperatively); | — |
Secondary
| Measure | Time frame |
|---|---|
| complications;length of stay;ESR,CRP,IL-6; | — |
Countries
China
Contacts
Public ContactGanjun Feng
Department of Orthopedics, West China Hospital, Sichuan University
Outcome results
None listed