ovarian cancer
Conditions
Interventions
experimental group :hyperthermic intraperitoneal chemotherapy
Sponsors
Department of Gynecologic Oncology,Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) FIGO stage IIIC-IVA,high-grade serous ovarian cancer (HGSOC); 2) Aged 18-70 years; 3) Fagotti >= 8, indicates that patients cannot undergo R0 primary debulking surgery; patients cannot endure primary debulking surgery; 4) Normal kidney function( blood creatinine 58-96 µmol/L); 5)Normal blood test (HBG >= 110 g/L, WBC >= 4.0 x 10^9/L, NEU >= 2.0 x 10^9/L, platelet >= 100 x 10^9/L); 6) Normal liver function (TBIL 3.4-22.2 µmol/L,ALT 7-40 U/L, AST 13-35 U/L AST/ALT <= 1.5); 7)World Health Organization performance-status score(WHO score) 0-2.
Exclusion criteria
Exclusion criteria: 1) Previous chemotherapy/radiotherapy/targeted therapy; 2) Complete intestine obstruction; 3) Expected life span <= 8 weeks; 4) Diagnosis of any other malignancy; 5) Poor cardiopulmonary function.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| chemotherapy response score CRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| progression free survival;overall survival;rate of residual 0 resection;adverse effect of HIPEC; | — |
Countries
China
Contacts
Public ContactJing Li
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
Outcome results
None listed