HCC
Conditions
Interventions
Sponsors
Zhongshan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients (over 18 years old) with unresectable / advanced pathologically confirmed HCC; 2. Patients who failed to receive first-line systemic therapy (chemotherapy, targeted therapy); 3. Patients with ECoG score 0 or 1; 4. Patients with child Pugh liver function grade A or B7; 5. Patients with at least three months' expected survival time; 6. Good liver, kidney and bone marrow function; total bilirubin 750000 / mm3, hemoglobin > 9 g / dl, neutrophil absolute value 1.5 x 500 / mm3; 7. Patients with HBV load less than 2000 IU / ml; 8. Patients without serious cardiopulmonary disease and normal cTnT & CK-MB index; 9. Patients who can provide pathological sections for gene testing and agree to sign the informed consent for research.
Exclusion criteria
Exclusion criteria: 1. Patients with uncontrollable hypertension (systolic blood pressure greater than 160 mm Hg or diastolic blood pressure greater than 100 mm Hg after active treatment); 2. Patients with history of esophageal or gastric bleeding in the last six months; 3. Patients with active infection who need systematic treatment; 4. Patients with previous malignant tumor except liver cancer; 5. Patients with HIV infection history; 6. Patients with history of bleeding or thromboembolism in the last month; 7. Patients who have received bone marrow / hematopoietic stem cell or organ transplantation; 8. The investigator defined the clinical condition as unsuitable for the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ORR;ACC, SPE, SEN; | — |
Countries
China
Contacts
Public ContactYin Xin
Zhongshan Hospital Affiliated to Fudan University
Outcome results
None listed