The Clinical Efficacy and Neural Correlates on Acupuncture for Lower Extremity Motor Rehabilitation of Post Ischemic Stroke: A Three-Armed Multi-Central Randomized Controlled Trial

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000038142

Enrollment

Unknown

Registered

2020-09-11

Start date

2020-10-01

Completion date

Unknown

Last updated

2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic stroke

Interventions

experimental group:"XNKQ" acupuncture

controlled group 1:"XNKQ" acupuncture+PT

controlled group 2:sham acupuncture+PT

Eligibility

Sex/Gender

All

Age

40 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Patients who meet the diagnostic criteria of ischemic stroke, and it is the first attack; 2. Patients with stable vital signs 2-14 days after stroke onset (GCS score > 8); 3. Basal ganglia (internal capsule) and (or) corona radiata infarction (diameter > 1.5cm), accompanied by lower extremity motor dysfunction (muscle strength <= 3), can be combined with upper limb motor dysfunction (NIHSS score 3-15); 4. Patients aged 40-70 years; 5. Right handed patients; 6. Patients who have informed consent and signed informed consent.

Exclusion criteria

Exclusion criteria: 1. The subjects who had been dependent on daily activities before the stroke; 2. Stroke patients who have received thrombolysis or thrombectomy treatment; 3. Infection of acupuncture site and (or) objects unable to tolerate acupuncture treatment; 4. Patients with other serious concomitant diseases (aphasia, moderate to severe edema of lower limbs, venous thrombosis of lower limbs, arteriosclerosis occlusion of lower limbs, diabetic lower extremity vascular disease, peripheral neuropathy, myelopathy, brain trauma, intracranial infection, brain tumor, etc.), secondary diseases (such as heart, liver, renal failure, etc.); 5. Patients with contraindications to MRI (claustrophobia, surgical implantation of metal devices, etc.); 6. Subjects with MMSE score: illiterate 17; Hamilton Anxiety Scale (HAMA) score >= 14.

Design outcomes

Primary

Measure	Time frame
Fugl-Meyer Assessment (FMA);multimodal MRI;	—

Secondary

Measure	Time frame
National Institutes of Health Stroke Scale (NIHSS);Modified Ashworth Scale (MAS);Manual Muscle Testing (MMT);Modified Barthel Index (MBI);Stroke Impact Scale (SIS-16);Efficacy Evaluation of Stroke of TCM;	—

Countries

China

Contacts

Public ContactChunhong Zhang

The First Affiliated Hospital of Tianjin University of traditional Chinese Medicine

drzch1113@tjutcm.edu.cn+86 13821537799

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026