Gestational Diabetes Mellitus
Conditions
Interventions
Intervention Group:Adhesive insulin pumps
Control Group :Multiple daily subcutaneous insulin injections
Sponsors
Shengjing Hospital Affiliated to China Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 20-45 years old; 2. Patients with body mass index (BMI) above 24.0 kg / m2; 3. Singleton pregnant women of 12-28 weeks gestation; 4. At present, the number of insulin injections per day was more than 2 times or insulin pump was used, and the daily dose was more than the body weight before pregnancy (kg) x 0.5; 5. Patients who can understand the purpose of the clinical trial voluntarily participate and sign the informed consent form; 6. Patients who can comply with the insulin treatment plan and medical nutrition guidance decided by the researcher; 7. Patients who are willing and able to use blood glucose meter to detect fingertip blood glucose and upload blood glucose data using mobile app as required.
Exclusion criteria
Exclusion criteria: 1. Patients who are known to be allergic to insulin, insulin analogues or ingredients in their preparations; 2. Study of gestational dominant diabetes mellitus (GDM); patients with suspected type 1 diabetes mellitus (T2DM); 3. The patients whose ALT and / or ast were more than 2.5 times of the upper limit of normal value; 4. EGFR = + 2 in routine urine examination; 5. Patients who were taking antihypertensive drugs at the time of enrollment; or systolic blood pressure >= 140mmHg and / or diastolic blood pressure >= 90mmHg; hypertension beyond control after treatment was defined as systolic blood pressure >= 140mmHg and / or diastolic blood pressure >= 90mmHg; 6. In vitro fertilization embryo transfer (IVF); 7. Patients with previous history of premature delivery (delivery before 37 weeks of gestation); or history of miscarriage in late pregnancy; placenta previa or cervical shortening received cerclage; 8. Patients who are taking glucocorticoid and heparin have SLE and anticardiolipin antibody syndrome 9. Patients with diseases related to glucose metabolism, such as hyperthyroidism, clinical hypothyroidism and steroid diabetes mellitus; 10. The study doctor judged that the patient's compliance was poor and could not complete the study according to the requirements, or other reasons were not suitable for participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pregnancy outcome; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood glucose related indexes;Dose of insulin;Incidence of preeclampsia;Indexes of metabolism; | — |
Countries
China
Contacts
Public ContactNa Wu
Shengjing Hospital Affiliated to China Medical University
Outcome results
None listed