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Effects of esmamine on EC50 of propofol TCI loss of consciousness and stress in elderly patients

Effects of esmamine on EC50 of propofol TCI loss of consciousness and stress in elderly patients

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000038125
Enrollment
Unknown
Registered
2020-09-11
Start date
2020-10-01
Completion date
Unknown
Last updated
2020-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Effects of esmamine on EC50 of propofol TCI loss of consciousness and stress in elderly patients

Interventions

4 groups:Objective to explore the effects of different doses of esmamine on EC50 of unconsciousness during target controlled infusion (TCI) of propofol, hemodynamics and stress hormones before and aft

Sponsors

Guiyang First People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 76 Years

Inclusion criteria

Inclusion criteria: 1. The patients were 65-75 years old, male and female, with BMI of 18.5-30.0kg/m2; 2. ASA grade I, II; 3. Patients undergoing elective surgery under general anesthesia

Exclusion criteria

Exclusion criteria: 1. There were patients who used glucocorticoid or non steroidal drugs recently; 2. Severe liver and kidney dysfunction, metabolic diseases; 3. Patients with severe bradyarrhythmia (HR < 50bpm) or type II or III block; 4. Mental illness or abuse of narcotic analgesics; 5. Hearing or intellectual impairment and poor communication; 6. Those who do not want to sign informed consent.

Design outcomes

Primary

MeasureTime frame
EC50;95%CI;—

Countries

China

Contacts

Public ContactYang Qin

Department of Anesthesiology, Guiyang First People's Hospital

2872818414@qq.com+86 13639013963

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026