Nonalcoholic fatty liver disease
Conditions
Sponsors
Shuguang Hospital affiliated to Shanghai University of TCM
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic standard of the nonalcoholic fatty liver disease; 2. Aged 18-65 years old; 3. MRI-PDFF is greater than or equal to 10%; 4. ALT is greater than the upper limit of normal, and less than or equal to 5 times the upper limit of normal; 5. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Those who have used other liver-protecting and enzyme-lowering drugs which might affect the efficacy evaluation in the past 3 months; 2. Patients with alcoholic fatty liver (male alcohol intake> 20g / d, female alcohol intake> 10g / d);Patients with cirrhosis, HBV, HCV and other liver diseases; Patients with autoimmune liver disease; People who are taking any drug which might cause fatty liver; 3. Those with normal liver function; 4. Those who have undergone gastrointestinal weight loss surgery in the past year or those who have lost weight by more than 10% after taking weight-loss drugs within the past 3 months; 5. Pregnant women, lactating women, patients with primary diseases such as cardiovascular, lung, kidney, hematopoietic system, and other major diseases such as malignant tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRI-PDFF; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum activity of ALT; liver stiffness measurements;weight;BMI;waistline;serum levels of TC;serum levels of TG;serum levels of LDL;serum levels of HDL-C;fasting blood-glucose;fasting insulin;insulin resistance index;SF-36;CLDQ NAFLD; | — |
Countries
China
Contacts
Public ContactQin Feng
Shuguang Hospital affiliated to Shanghai University of TCM
Outcome results
None listed