non-Hodgkin's lymphoma
Conditions
Interventions
treatment group:chinese medical+R-CHOP
control group:R -CHOP
Sponsors
The First Affiliated Hospital of Zhejiang Chinese Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients with grade I-II follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia / small cell lymphoma (CLL / SLL) were diagnosed as grade I-II follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia / small cell lymphoma (CLL / SLL) according to the revised WHO classification of lymphoid system tumors in 2016 and the lymphoma classification criteria of NCCN guidelines in 2019; (2) The age ranged from 18 to 80 years old; (3) During the treatment period, antibiotics were used within one month before sampling; (4) No digestive tract related diseases occurred within 3 months; (5) The body mass index was in the normal range; (6) PS <= 2 in physical condition assessment; (7) Patients must provide written informed consent and have not participated in other clinical studies.
Exclusion criteria
Exclusion criteria: (1) Chinese medicine, antibiotics or probiotics were used in the past 3 months; (2) There are intestinal diseases; (3) The body weight was not in the normal range (BMI = 25); (4) There are heart, liver, kidney and other important organ complications or other tumors; (5) There are autoimmune diseases; (6) Pregnancy or breastfeeding; (7) Participating in other intervention studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut microbiome Genome testing;Lymphocyte subsets; | — |
Countries
China
Contacts
Public ContactJianping Shen
The First Affiliated Hospital of Zhejiang Chinese Medical University
Outcome results
None listed