Neurodevelopmental, genetic, metabolic diseases and mental disorders in children and adolescents
Conditions
Interventions
Case group:None
Control group:none
Sponsors
Capital Institute of Pediatrics
Eligibility
Sex/Gender
All
Age
No minimum to 6 Years
Inclusion criteria
Inclusion criteria: 1) Children with ASD and ID/DD less than 6 years old; 2) for children less than 3 years old, neuropsychological and behavioral assessment is needed, and the scale indicates that any two of the three dimensions (see experimental means) are lower than the specified score; 3) for children older than 3 years old, families are required to provide the basis for the existence of the above symptoms before the age of 3 and the corresponding medical data; 4) Blood and urine metabolism, blood biochemistry and chromosome tests are normal; 5) there are no other systematic malformations.
Exclusion criteria
Exclusion criteria: 1) Identify patients with NDD phenotype due to high fever and brain infection / injury / surgery; 2) patients with metabolic diseases indicated by hematuria metabolic screening; 3) patients with ASD or ID with previous genetic diagnosis (chromosomal disease, genomic disease, genetic metabolic disease, mitochondrial disease, panel sequencing); 4) patients with simple convulsion / epilepsy / ADHD.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gene mutation site; | — |
Countries
China
Contacts
Public ContactXiaoliChen
Capital Institute of Pediatrics
Outcome results
None listed