Skip to content

Application of remidazolam in gastroscopy of patients with hypertension

Effect of remidazolam toluenesulfonate on hemodynamics and recovery time in patients with hypertension undergoing gastrointestinal endoscop

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000038070
Enrollment
Unknown
Registered
2020-09-09
Start date
2020-09-14
Completion date
Unknown
Last updated
2020-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Interventions

Sponsors

Liaocheng People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Hypertensive patients, age 65yr-70yr, gender is not limited; in the case of not using antihypertensive drugs, blood pressure was measured 3 times on different days, systolic blood pressure >= 140mmHg and (or) diastolic blood pressure >= 90mmHg or a clear diagnosis of hypertension Elderly people who are being treated with antihypertensive drugs should still be included in the group even if their blood pressure is < 140/90mmHg. 2. Patients receiving routine gastroscopy diagnosis and treatment; 3. The ASA score is level II and level III; 4. 18 kg/m2 < BMI < 30kg/m2 5. It is estimated that the operation time of gastroscope will not exceed 30 minutes; 6. Clearly understand, participate in the research voluntarily, and sign an informed consent form.

Exclusion criteria

Exclusion criteria: 1. Complicated endoscopic diagnosis and treatment techniques (such as cholangiopancreatography, endoscopic ultrasound, endoscopic mucosal resection, endoscopic submucosal dissection, oral endoscopic muscle dissection, etc.) are required; 2. Patients who intend to undergo tracheal intubation; 3. Patients who are judged to be difficult to manage the respiratory tract (modified Markov score is grade IV); 4. Anemia or thrombocytopenia, Hb = 2.5 x ULN, TBIL >= 1.5 x ULN; 6. Abnormal renal function, blood creatinine is greater than the upper limit of normal; 7. There is a history of drug abuse and/or alcohol abuse within 2 years before the beginning of the screening period, alcohol abuse means that the average daily alcohol consumption exceeds 2 units of alcohol (1 unit = 360 mL of beer or 45 mL of 40% alcoholic liquor or 150 mL of wine); 8. Sitting systolic blood pressure <= 90 mmHg during the screening period; 9. Women who are pregnant or breastfeeding; 10. Those who are allergic or contraindicated to benzodiazepines, opioids, propofol, lidocaine and their drug components; 11. Participated in drug clinical trials as subjects in the past 3 months; 12. The investigator believes that it is inappropriate to participate in this trial.

Design outcomes

Primary

MeasureTime frame
blood pressure;

Secondary

MeasureTime frame
heart beats;Pulse oxygen saturation;Recovery time;

Countries

China

Contacts

Public ContactLiangmin

Liaocheng People's Hospital

liangmin861016@163.com+86 15163511260

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026