Th1/Th2 balance drift in human body under high PM2.5 exposure
Conditions
Interventions
low exposure group A:Oral mega-3 fatty acids
low exposure group B:Oral placebo
high exposure group A:Oral mega-3 fatty acids
Sponsors
The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for people with high PM2.5 exposure: (1) The staff in Chengdu Metro Station Hall, male or female, age: 20-65 years old, working in the station hall >= 3 times per week, working time >= 8 hours per day, and working time >= 2 years; (2) Those who have had no obvious abnormalities in the physical examination in the past year; (3) No hormone preparations have been used in the past 3 months; (4) No history of surgery in the past three months; (5) Informed consent to join this experimental study and sign the informed consent form. Inclusion criteria for people with low PM2.5 exposure: (1) The staff in the office of Chengdu Metro Station Hall (air-conditioning device equipped with PM2.5 filters), regardless of gender, age: 20-65 years old, working >= 3 times per week, working hours >= 8 per day Hours, working time >= 2 years; (2) Those who have had no obvious abnormalities in the physical examination in the past year; (3) No hormone preparations have been used in the past 3 months; (4) No history of surgery in the past three months; (5) Informed consent to join this experimental study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Those with a long-term history of drug use; (2) Those who have a history of smoking; (3) Those with a history of massive bleeding; (4) Those who are allergic to flaxseed, fish and seafood; (5) Those with a history of hepatitis, fatty liver, cirrhosis, cholecystitis, and gallstones; (6) Those who are pregnant and lactating; (7) Participants in other clinical trials in the past 6 months; (8) Those who cannot understand the intention of this experiment and are difficult to cooperate with the experiment process.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Th1 and Th2 cell levels and the ratio of the two;Th1 and Th2 cytokine levels; | — |
Secondary
| Measure | Time frame |
|---|---|
| Levels of IL-4 and INF-? in nasal lavage fluid;IL-8 and ICAM-1 levels in serum;Serum levels of hypersensitivity C-reactive protein;Pulmonary function;SF-36;COOP/WONCA chart;Otolaryngology, Respiratory and Cardiovascular Department Visits and Follow-up Record Form; | — |
Countries
China
Contacts
Public ContactShuiqin Li
The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine
Outcome results
None listed