Clinical Study of Ulinastatin on Lung Protection During the Perioperative Period in Patients with Acute Type A Aortic Dissection Undergoing Deep Hypothermic Circulatory Arrest

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000038052

Enrollment

Unknown

Registered

2020-09-09

Start date

2020-09-01

Completion date

Unknown

Last updated

2020-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute type A aortic dissection

Interventions

blank control group:none

intervention group:use ulinastatin during perioperative period

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: The patients are conformed to 2010 ACC/AHA guidelines for the diagnosis and treatment of thoracic aortic disease (TAD) within two weeks of onset; Patients with acute type A aortic dissection confirmed clinically and radiologically and planning to undergo emergency manual surgery were enrolled. The patients' age between 18 ~70 years old, weight 50 kg to 80 kg; The patients need to sign the informed consent.

Exclusion criteria

Exclusion criteria: The patients with moderate and large pericardial effusion and pleural effusion before operation. Patients with pre-existing cardiopulmonary disease, neurological disease, hematologic disease, liver and kidney dysfunction, infection, thrombotic disease, etc. The patients who did not sign informed consent.

Design outcomes

Primary

Measure	Time frame
Mechanical ventilation time of ventilator;oxygenation index;	—

Secondary

Measure	Time frame
PEEP;IL-6;IL-8;	—

Countries

China

Contacts

Public ContactZhu Junming

Beijing Anzhen Hospital, Capital Medical University

anzhenzjm@163.com+86 13801132276

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026