The study on the safety and feasibility of non-intubation anesthesia with spontaneous respiration in thoracoscopy

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000038041

Enrollment

Unknown

Registered

2020-09-09

Start date

2020-09-01

Completion date

Unknown

Last updated

2020-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thoracic surgery

Interventions

S group:Non-tracheal intubation spontaneous breathing

D group:double-lumen tube intubation with single-lung ventilation

Eligibility

Sex/Gender

All

Age

20 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. There are no contraindications for anesthesia, no serious underlying diseases, no heart, liver and kidney dysfunction before operation. 2. There was no history of surgery on the affected chest cavity. Preoperative examination showed no serious adhesions or calcification in the chest cavity. 3. No excessive obesity or predictable difficult airway, body mass index <25 kg / m2, Mallampati classification: grade I-II. 4. Normal lung function or only mild ventilation dysfunction, preoperative blood gas analysis, arterial blood PaCO2 <= 50 mmHg (1mmHg = 0.133kPa). 5. No severe anxiety or depression. 6. No severe coagulation dysfunction. 7. Patients all agreed to perform non-tracheal intubation thoracoscopic surgery, and understood the risk of conversion to general anesthesia and double-lumen intubation thoracoscopy.

Exclusion criteria

Exclusion criteria: 1. ASA (American Society of Anesthesiologists) standard >= III, combined with severe heart, lung, liver, and kidney dysfunction; 2. Obesity (body mass index >= 25kg / m2); 3. Abnormal airway, difficult and predictable airway; 4. Respiratory tract infections, increased secretions, and difficulties in respiratory tract management; 5. Bronchiectasis, asthma; 6. There is a high risk of reflux and aspiration of stomach contents; 7. Sleep apnea; 8. Unstable circulatory system and decompensated heart disease; 9. Coagulation dysfunction and other bleeding diseases (international standardized ratio > 1.5); 10. Those with neurological diseases who are unable to cooperate; 11. The pleura is extensively adhered, and the surgical operation is restricted or > 6cm or the tumor in the central position; 12. Hypoxemia (PaO2 50mmHg), poor lung function (FEVl% < 60%); 13. Central hypoventilation syndrome, etc.

Design outcomes

Primary

Measure	Time frame
IL-6;IL-8;TNF-a;SPA??;AQP-5;HMGB1;Hemodynamics;Postoperative recovery index;Inflammatory factors associated with lung injury;Lung injury related protein;	—

Countries

China

Contacts

Public ContactLingfei Wang

Liaoning Cancer Hospital & Institute

wanglingfei.good@163.com+86 18900918433

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026