Postoperative analgeisa
Conditions
Interventions
A group:30 ml 0.25% ropivacaine+ 5mg dexamethasone + 0.5 ug/kg dexmedetomidine (each side)
B group:30 ml 0.25% ropivacaine+ 5mg dexamethasone (each side)
C group:30 ml 0.25% ropivacaine+ 0.5 ug/kg dexmedetomidine (each side)
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients were 18 years of age or older; 2. With American Society of Anesthesiologists (ASA) physical status I–III; 3. Schedule for gastric cancer surgery under general anesthesia; 4. Inform consent signed.
Exclusion criteria
Exclusion criteria: 1. With contraindications to nerve block (e.g. infection at puncture site); 2. With difficulty for communication; 3. Body Mass Index (BMI) below 18.5 kg/m^2 or over 30 kg/m^2; 4. Preoperative examination indicating metastasis; 5. With chronic pain (last over three months) or chronic opioid use (over 60 mg of oral morphine or equivalent per day); 6. With contraindications to any drugs used in the study; 7. Participated in other clinical trials within three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| INcidence of moderate-to-severe pain on movement at 24 h after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS score;Opioids consumption;The duration of the first rescue analgesia;Time of first getting out of bed;Time of first exhausting;Incidence of adverse events including intraoperative hypotension, intraoperative bradycardia, intraoperative hypertension, postoperative nausea and vomiting (PONV), pruritus, dizzy, respiratory depression, pulmonary infection, surgical site infection, urinary tract infection, bloodstream infection, sepsis (Septic shock);Length of hospital stay;Postoperative recovery quality;Incidence of moderate-to-severe pain;Time to gastric tube removal;Time to urine catheter removal;The proportion of first request of rescue analgesia;Incidence of moderate-to-severe pain on movement;Hospitalization cost;Incidence of chronic pain; | — |
Countries
China
Contacts
Public ContactLi Qian
West China Hospital, Sichuan University
Outcome results
None listed