Knee osteoarthritis
Conditions
Sponsors
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients who meet the diagnostic criteria of ACR for knee arthritis in 1991; 2. Patients aged between 40 and 60 years with right hand and left knee pain; 3. Whether the I-II X-ray changes of knee joint conform to Kellgren Lawrence scale; 4. Patients with average knee pain score >=3 (range from 0 to 10) in the past three months; 5. Patients who voluntarily participated in the study and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who have taken analgesics or anesthetics that may affect the results of brain imaging in the past month; 2. Patients who have received other treatment in the past month; 3. Pregnant women or lactating women; 4. Patients with chronic pain symptoms such as mental disease, nervous system disease, infectious disease, gastrointestinal disease, cardiovascular disease, immune system disease, respiratory system disease or kidney disease, or history of brain injury and loss of consciousness; 5. Patients diagnosed with cancer, tuberculosis, rheumatism or rheumatoid arthritis, gout and joint trauma; 6. Patients with claustrophobia, pacemaker, defibrillator, cardiac stent, intrauterine device and other contraindications of MRI; 7. Patients with skin injury around the knee joint.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Visual Analog Scale (VAS);fMRI - functional connectivity (FC);structure - gray matter density, cortical thickness, subcortical nuclei volumes;diffusion - FA and MD of white matter integrity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Short-form McGill Pain Questionnaire (SF-MPQ);Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC);the 36-Item Short Form Health Survey (SF-36);Hamilton Depression Scale (HAMD);the Hamilton Anxiety Scale (HAMA); | — |
Countries
China
Contacts
Public ContactZhu Qingguang
Yueyang Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Shanghai University of traditional Chinese Medicine
Outcome results
None listed