General anesthesia
Conditions
Interventions
Opioid analgesic group:Use opioids analgesic for analgesia
Esmolamine group:Use of esmolamine for analgesia
Sponsors
The Second Hospital of Shanxi Medical University
Eligibility
Sex/Gender
All
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients with informed consent; 2. Patients undergoing elective noncardiac surgery under general anesthesia; 3. ASA I-III patients; 4. Patients aged 20-75 years.
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications of general anesthesia; 2. Patients who are allergic or intolerant to ketamine hydrochloride, esketamine hydrochloride, propofol, rocuronium, opioids, neostigmine and belladonna alkaloids; 3. Patients who have used narcotic analgesics within 24 hours or within 5 days; long-term (continuous or intermittent) use of benzodiazepines and opioids; 4. Patients with abnormal coagulation function (Pt or r-inr > 1.5 ULN, APTT >1.5 ULN) have bleeding tendency (such as active gastrointestinal ulcer) or are receiving thrombolytic or anticoagulant therapy; 5. Anemia or thrombocytopenia, PLT =1.5 ULN, TBIL >=1.5 ULN; 7. In patients with abnormal renal function, bun >= 1.5 ULN and creatinine exceeding the upper limit of normal value; 8. Patients with a history of serious cardiovascular diseases (such as myocardial ischemia, cardiac dysfunction, arrhythmia, etc.); angina pectoris (unstable angina pectoris) due to insufficient coronary artery blood supply, or myocardial infarction in recent 6 months; 9. Patients with hypertension whose blood pressure has not been controlled satisfactorily by using antihypertensive drugs (SBP >=160 mmHg and / or DBP >=100mmhg); 10. Patients with craniocerebral injury, possible high intracranial pressure, cerebral aneurysm, cerebrovascular accident disease history and other central nervous system diseases; 11. Patients with diabetes whose blood glucose was not controlled satisfactorily (blood glucose >=11.1 mmol/L); 12. Patients with a history of drug abuse and / or alcoholism within 2 years; alcoholism, i.e. drinking more than 2 units of alcohol per day on average, (1 unit of alcohol = 360ml of beer or 150 ml of 45 ml of strong liquor with 40% alcohol content); 13. Pregnant or lactating women; 14. Patients with hyperthyroidism and / or history of hyperthyroidism; 15. Patients with a history of high intraocular pressure (e.g. glaucoma) or penetrating eye injury; 16. Patients with abnormal lipid metabolism, including primary hyperlipidemia, diabetic hyperlipidemia and pancreatitis; 17. Patients with mental illness and / or history (including schizophrenia, mania, bipolar disorder, mental disorder, etc.) and the use of psychotropic drugs, i.e. cognitive impairment; 18. Patients with asthma disease and / or history; 19. Patients with difficult airway (modified Mahalanobis score was grade IV); 20. Patients who have received clinical trials of drugs in the past three months; 21. Patients considered unsuitable for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Abnormal hemodynamic fluctuations;Arrhythmia;Myocardial ischemia;miocardial infarction;Acute heart failure;Cardiac arrest;TRPV1 content;CGRP content;SP content;cTnI content; | — |
Secondary
| Measure | Time frame |
|---|---|
| Drug dosage;Blood loss;Urine volume;fluid replacement volume;NRS pain score;Restlessness score;Determination of recovery time of directional force; | — |
Countries
China
Contacts
Public ContactGuo Zheng
The Second Hospital of Shanxi Medical University
Outcome results
None listed