Airway malignant tumor
Conditions
Interventions
routine treatment group:Laser, high frequency electrotome, argon plasma coagulation (APC), hard mirror elimination, freezing, airway stents, balloon dilatation and other treatments
PDT treatment group:Laser irradiation was performed for about 20 minutes 48 ~ 72 hours after intravenous infusion of photosensitizer
Sponsors
He'nan Provincial People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. The age of male and female is 18-75 years old (including 18 and 75 years old); 2. Patients with early central lung cancer; primary malignant tumor of trachea; Severe dysplasia of trachea and bronchus should meet the following conditions: malignant tumor or precancerous lesion confirmed by pathology, CT, EBUS, optical coherence tomography (OCT), narrow band imaging (NBI) or fluorescence bronchoscopy (FBI) Bronchoscope (AFB) confirmed that the lesion involved mucosa and submucosa, but not cartilage and adventitia. The length was less than 1 cm and the depth of invasion was less than 1 cm within the scope of bronchoscope. There was no lymph node and distant metastasis. The patient could not tolerate surgery or did not accept surgical treatment. 3. The subjects could tolerate general anesthesia, bronchoscopy and airway therapy; 4. Patients who are fully informed of the purpose and content of the trial agree to participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Porphyria and other diseases aggravated by light; 2. Patients known to be allergic to hematoporphyrins or any excipients; 3. Patients who are being treated with photosensitizer now; 4. Patients scheduled for surgery within 30 days; 5. Patients with ophthalmic diseases who need light examination within 30 days; 6. Patients with severe cardiopulmonary dysfunction, liver and kidney dysfunction who can not tolerate bronchoscopy; 7. Patients with obvious coagulation dysfunction; 8. Patients with tumor invasion of large blood vessels, tracheoesophageal tumor penetrating infiltration; 9. Patients with tracheoesophageal fistula, tracheo mediastinal fistula, bronchopleural fistula, and the destruction of bronchial tube wall structure; 10. The patients with tracheal tumor to severe stenosis (> 75%) were not allowed to undergo photodynamic therapy directly; 11. Patients with mixed lesions mainly with Extraductal type; 12. Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement rate of stenosis degree;Improvement in lung function;Incidence of postoperative complications;overall survival;progression free survival; | — |
Countries
China
Contacts
Public ContactXiaoju Zhang
He'nan Provincial People's Hospital
Outcome results
None listed