Myasthenia gravis
Conditions
Interventions
Case series:statin
Sponsors
Qianfoshan Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Refer to the Chinese guidelines for the diagnosis and treatment of myasthenia gravis 2015 for patients with myasthenia gravis; 2. Patients aged 50-80 years with stable type I and type II senile Mg (MGFA classification); 3. Patients with ASCVD risk factors such as diabetes mellitus and hyperlipidemia; 4. The patient had no contraindications of hormone and other immunosuppressants and statins, and had signed the informed consent for treatment; 5. Patients with good compliance and regular outpatient or telephone follow-up; 6. Patients who did not use drugs that affect the outcome of this study one week before enrollment, such as NSAIDs, steroids, immunosuppressants other than aza and hormones.
Exclusion criteria
Exclusion criteria: 1. Patients with severe visceral diseases and liver and kidney dysfunction; 2. Patients with cognitive impairment and mental retardation; 3. Patients with serious incomplete clinical data; 4. Patients with acute cardiovascular and cerebrovascular events; 5. Patients who take traditional Chinese medicine to control their condition; 6. Patients with acute infection; 7. Patients with respiratory muscle involvement or recent myasthenia crisis; 8. In patients with active liver disease, the serum transaminase continued to exceed 3 times of the normal limit and the cause was unknown; 9. Any other circumstances considered unsuitable by the investigator to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Activity daily life Scale;Quantitive MG score; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-6, IL-10, IL-17, IL-21;Serum levels of anti-ACHR antibodies; | — |
Countries
China
Contacts
Public ContactDuan Ruisheng
Qianfoshan Hospital
Outcome results
None listed