Clinical Value of Metagenomic Next- Generation Sequencing in Patients with Severe Community-Acquired Pneumonia: a Multicenter Prospective Randomized Controlled Study

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000037894

Enrollment

Unknown

Registered

2020-09-04

Start date

2020-12-01

Completion date

Unknown

Last updated

2020-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe Community-acquired Pneumonia

Interventions

experimental group:NGS test

control group:Routine microbiological test

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Patients with age >= 18 years old; 2. Patients admitted to ICU; 3. Patients who meet the diagnostic criteria of "severe community acquired pneumonia"; 4. Patients who agree to bronchoscopy; 5. Patients or their agents sign informed consent.

Exclusion criteria

Exclusion criteria: 1. The patients who stay in the nursing home for a long time; 2. Patients after tracheotomy; 3. Patients who were admitted to ICU because of cap but needed to be admitted to ICU due to aggravation of HAP; 4. Contraindications of bronchoscopy; 4; 5. Patients who failed to complete the bronchoscopy examination within 72 hours after admission; 6. Patients who participated in other clinical studies.

Design outcomes

Primary

Measure	Time frame
Time of clinical improvement within 28 days;	—

Secondary

Measure	Time frame
ICU mortality;	—

Countries

China

Contacts

Public ContactQingyuan Zhan

Chian-Japan Friendship Hospital

zhanqy0915@163.com+86 13911785957

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 6, 2026