General anesthesia for day surgery
Conditions
Interventions
Trial group:Remazolam tosylate and fat emulsion for injection are used for intravenous induction, and remazolam tosylate, fat emulsion and remifentanil for injection are used for intravenous maintenan
Control group:Equipped with saline, propofol for intravenous induction, saline, propofol, and remifentanil for intravenous maintenance
Sponsors
The First People's Hospital of Lianyungang
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients with 18 <= age < 65 years old, regardless of gender; 2. The operation time was less than 2 hours in patients with selective operation; 3. Patients with ASA grade I or II; 4. Patients with 18 kg / m2 < BMI < 30 kg / m2; 5. Clearly understand and voluntarily participate in the study, and their informed consent form is signed by themselves.
Exclusion criteria
Exclusion criteria: 1. Patients undergoing emergency surgery; hypovolemia, shock or coma; 2. Patients who need other anesthesia besides general intravenous anesthesia, such as inhalation anesthesia, epidural anesthesia, subarachnoid anesthesia, etc; 3. Patients with infectious heart diseases, such as myocarditis or endocarditis; sepsis; and; 4. Patients with uncontrolled hypertension, diabetes, heart failure, etc; 5. In patients with abnormal liver function, AST and / or ALT >= 2.5 x ULN, TBIL >=1.5 x ULN; 6. In patients with abnormal renal function, urea or urea nitrogen >= 1.5 x ULN and serum creatinine higher than the upper limit of normal value; 7. Patients with mental system diseases (schizophrenia, mania, bipolar disorder, mental disorder, etc.) and those with long-term history of taking psychotropic drugs and cognitive dysfunction; 8. Pregnant or lactating women; 9. Patients with allergies or contraindications to benzodiazepines, opioids, propofol, muscle relaxants and their components; 10. Other situations in which the researcher considers it inappropriate to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anesthesia and sedation success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of hypotension during induction of anesthesia;Anesthesia recovery time;Incidence of intraoperative awareness; | — |
Countries
China
Contacts
Public ContactZhao Zhibin
The First People's Hospital of Lianyungang
Outcome results
None listed