Urosepsis
Conditions
Interventions
Gold Standard:Urosepsis can be diagnosed if:European diagnostic criteria for sepsis Sepsis 3.0
Sequential organ failure score in patients with infection or suspected infection(SOFA)>= 2
Quick SOFA(qSOFA) >= 2.
Index test:Heparin-binding 
protein
 
Serum 
A 
Sponsors
Huashan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
16 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. The patients with renal and / or ureteral calculi confirmed by imaging examination were treated with minimally invasive surgery (percutaneous nephrolithotomy / rigid ureteroscopy / flexible ureteroscopy). 2. Patients without bloodstream infection / urinary sepsis before operation: no fever, white blood cell and neutrophil ratio in normal range. 3. The patients whose urinary tract infection had been controlled before operation met the requirements of endovascular minimally invasive surgery: urinary WBC count < 50 / µ L. (if complicated with pyonephrosis, adequate drainage and anti infective treatment should be taken before operation.) 4. Patients without systemic infection before operation, such as pneumonia, biliary tract infection, enteritis, soft tissue infection, etc.
Exclusion criteria
Exclusion criteria: 1. Patients with urinary tract special pathogen infection, such as urinary tuberculosis infection, anaerobic bacteria infection, extensively drug-resistant bacterial infection, etc. 2. Patients with serious mental illness. 3. Patients with untreated malignant tumor or immune system diseases. 4. Patients with long-term use of immunosuppressants or glucocorticoids. 5. Patients with severe organ dysfunction. 6. Subjects of pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heparin-binding protein;Serum amyloid A protein;Presepsin;interleukin-6;Soluble urokinase-type plasminogen activator receptor;Soluble triggering receptor expressed on myeloid cells-1;CD64;SEN, SPE, ACC, AUC of ROC; | — |
Secondary
| Measure | Time frame |
|---|---|
| C-reactive protein;procalcitonin; | — |
Countries
China
Contacts
Public ContactZhong Wu
Huashan Hospital Affiliated to Fudan University
Outcome results
None listed