The effects of different doses S-ketamine on postoperative congnitive dysfunction and postoperation pain in orthopedic patients

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000037818

Enrollment

Unknown

Registered

2020-09-02

Start date

2020-12-01

Completion date

Unknown

Last updated

2020-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative congnitive dysfunction

Interventions

control group:After induction of anesthesia, 0.9%NS was injected under load, and then 0.9%NS was continuously pumped into the suture?

minimal-dose S-ketamine group:After anesthesia induction, 0.9%NS was injected under load, and 0.125 mg/kg/h dextrorotatory ketamine was continuously pumped into the suture

low-dose S-ketamine group:After anesthesia induction, 0.25 mg/kg dextroketamine was injected under load, and 0.125 mg/kg/h dextroketamine was continuously pumped into the suture

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 60 patients undergoing elective orthopedic surgery, aged > 18 years old, weight 40-120kg, ASA I-III.

Exclusion criteria

Exclusion criteria: Refused existing neurological or psychiatric disease in patients with chronic pain syndrome any acute or chronic pain states opioid treatment of alcohol or drug abuse, rheumatoid arthritis of knee joint surgery serious liver and kidney dysfunction, severe coronary artery disease pregnant alcohol or opioid addiction communication difficulties and poor compliance

Design outcomes

Primary

Measure	Time frame
NRS scores;TNF-a;IL-6;S100-ß;NSE;GFAP;WAIS-WMS-IV??;hyperpathia;	—

Countries

China

Contacts

Public ContactYing Cao

The Second People's Hospital of Guiyang

9247625@qq.com+86 13985463336

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026