Application of ultrasound-guided brain and lung dual protective ventilation strategy for patients with acute brain injury and moderate to sever acute respiratory distress syndrome

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000037804

Enrollment

Unknown

Registered

2020-09-02

Start date

2020-09-01

Completion date

Unknown

Last updated

2020-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute respiratory distress syndrome

Interventions

Focal ARDS vs diffuse ARDS:positive end-expiratory pressure

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged at least 18 years; 2. Acute brain injury (including traumatic brain injury hemorrhagic/ischemic stroke subarachnoid hemorrhage) 3. Glasgow Coma Score less than or equal to 8; 4. Moderate or severe ARDS diagnosed according to the Berlin definition.

Exclusion criteria

Exclusion criteria: 1. Haemodynamic instability requiring more than 10 µg/kg/min dopamine or more than 0.5 µg/kg/min norepinephrine; 2. ICP > 25 mmHg; 3. CPP < 60 mmHg 4. Decompressive craniectomy was performed; 5. Evidence of active air leak from the lung, including bronchopleural fistula, pneumothorax, pneumomediastinum or existing chest tube; 6. History of chronic obstructive pulmonary disease; 7. Known pregnancy; 8. Patients already enrolled in one other intervention study.

Design outcomes

Primary

Measure	Time frame
brian oxygen index;	—

Secondary

Measure	Time frame
blood flow velocity of Middle cerebral artery at M1;Cerebral perfusion pressure;respiratory mechanic index;Gas exchange index;	—

Countries

China

Contacts

Public ContactTang Rui

The Frist Affiliated Hospital of University of Science and Technology of China

drtangru@ustc.edu.cn+86 18656553280

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026