Stroke
Conditions
Interventions
Experimental Group:central combined peipheral rTMS
Control Group:traditional central rTMS
Sponsors
Third affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 20-70 years; 2. The patients with cerebrovascular diseases who met the diagnostic criteria of "diagnostic points of various cerebrovascular diseases, 1996" revised by the Fourth National Academic Conference on cerebrovascular diseases, were confirmed by CT or MRI scan; 3. Patients with initial or recurrent cerebral hemorrhage or cerebral infarction; 4. Patients with stable vital signs who can cooperate with the completion of treatment and evaluation; 5. Patients with limb dysfunction and lower limb muscle strength >=3 on the hemiplegic side; 6. Patients without contraindications of MRI and TMS; 7. MMSE (minimum mental state examination) >=10 points in patients without severe cognitive impairment; 8. Patients without pulmonary bullae, emphysema, pneumothorax and other basic lung diseases; 9. All the patients agreed to be the subjects and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with metal foreign body, pacemaker, cardiac stent and cochlear implant in the head; 2. Patients with severe heart, lung, liver, kidney dysfunction and other complications, malignant tumor; 3. Patients with severe cognitive and language dysfunction; 4. Patients with previous craniocerebral trauma, encephalitis and other intracranial diseases; 5. Patients with diseases that seriously affect the feeling and movement of limbs, such as rheumatoid arthritis, lumbar disc herniation, upper limb trauma and other peripheral neuropathy; 6. Patients with epilepsy or mental disorders in the past; 7. Patients with increased intracranial pressure; 8. Patients with massive hemoptysis and aortic aneurysm in recent 4 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Forced vital capacity;FEV1;FEV1/FVC;maximum expiratory velocity;maximum midexpiratory flow;maximal ventilatory volume;upper limb reflex myoelectric threshold;upper limb root-mean-square,RMS;upper limb iEMG;timed up and go test; | — |
Secondary
| Measure | Time frame |
|---|---|
| respiratory muscle surface myoelectricity;diaphragm movement velocity;muscle tone of limb muscles;physical function of limbs;walking speed;activities of daily living; | — |
Countries
China
Contacts
Public ContactQing Cai
The Third Affiliated Hospital of Sun Yat sen University
Outcome results
None listed