A Randomized Controlled Clinical Study of Early Intervention in Individuals at High Risk for Alzheimer's Disease by using Paired Associates Learning (PAL) based on Hippocampal Activation

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000037778

Enrollment

Unknown

Registered

2020-09-01

Start date

2020-10-01

Completion date

Unknown

Last updated

2020-11-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

early Alzheimer's disease

Interventions

Intervention group:PAL cognitive training

Control group:Convenience care

Eligibility

Sex/Gender

All

Age

60 Years to 85 Years

Inclusion criteria

Inclusion criteria: (1) Patients with mild cognitive impairment (MCI); (2) Aged >=60 years; (3) Normal vision, hearing and pronunciation; (4) Ability to operate a smart phone or tablet computer; (5) Participants and/or their legal guardians agree to participate in the study and sign informed consent.

Exclusion criteria

Exclusion criteria: (1) Severe schizophrenia or mental retardation; (2) The intervention content and related examinations cannot be completed because of severe chronic diseases; (3) Refuse to participate in this study.

Design outcomes

Primary

Measure	Time frame
Change in MMSE score before and after the intervention;	—

Secondary

Measure	Time frame
Change in score of every neuropsychological test;Change in brain structure of MRI;Change in PET indexes;Change in plasma biomarkers;	—

Countries

China

Contacts

Public ContactDing Ding

Huashan Hospital Affiliated to Fudan Hospital

dding99@163.com+86 13916461090

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026