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Effect of strict individualized blood pressure management strategy on postoperative acute kidney injury among elderly hypertensive patients undergoing major abdominal surgery: a randomized clinical trial

Effect of strict individualized blood pressure management strategy on postoperative acute kidney injury among elderly hypertensive patients undergoing major abdominal surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000037777
Enrollment
Unknown
Registered
2020-09-01
Start date
2020-09-04
Completion date
Unknown
Last updated
2020-11-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative acute kidney injury

Interventions

Experimental group:MAP was targeted to remain within ±10% of the reference value using a continuous infusion of norepinephrine.
Control group:Continuous infusion of norepinephrine to maintain arterial blood pressure = 80 mmHg.

Sponsors

Department of Anesthesiology, Huashan Hospital of Fudan University
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Aged 65 years or older; 2. Patients who had chronic hypertension; 3. American Society of Anesthesiologists physical status of class II or higher, 4. Scheduled to undergo major abdominal surgery under general anesthesia with an expected duration of 2 hours or longer; 5. Informed consent has been signed.

Exclusion criteria

Exclusion criteria: 1. Chronic kidney disease (glomerular filtration rate <30 mL/min/1.73m2 or requiring renal replacement therapy for end-stage renal disease); 2. Acute or decompensated heart failure or acute coronary syndrome; 3. Preoperative sepsis or were already receiving norepinephrine infusion; 4. Urological surgery; 5. Enrolled in another study.

Design outcomes

Primary

MeasureTime frame
Incidence of AKI within the first 7 days after major abdominal surgery.;—

Secondary

MeasureTime frame
Incidence of subclinical AKI within the first 7 days after major abdominal surgery.;Stay in ICU;Hospital acquired;Death at day 30;Perioperative adverse complications;—

Countries

China

Contacts

Public ContactYINGWEI WANG

Department of Anesthesiology, Huashan Hospital of Fudan University

wangyw@fudan.edu.cn+86 18801903283

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026