Advanced Non-Small Cell Lung Cancer
Conditions
Interventions
Sponsors
Dongfang Hospital Affiliated to Tongji University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Volunteer to join this study and sign an informed consent form; 2. Aged 18-75 years old; 3. Non-small cell lung cancer, subjects who have not benefited from conventional standard treatment; 4. According to imRECIST evaluation criteria, there is at least one measurable lesion; 5. Expected survival period >=3 months; 6. The Eastern Cooperative Oncology Group (ECOG) score is 0 or 1; 7. The following hematological indicators need to be met: neutrophil count >=1.5x10^9/L; hemoglobin >=10.0 g/dL; platelet count >=50x10^9/L; The following biochemical indicators need to be met: total bilirubin <=2.0 ULN; AST and ALT <=2.0 ULN; serum creatinine <=1.5 ULN.
Exclusion criteria
Exclusion criteria: 1. Subjects infected with HBV, HCV, HIV, syphilis and tuberculosis; 2. Uncontrollable coronary artery disease or asthma, uncontrollable cerebrovascular disease or other diseases considered by the researcher to be incompatible with the group; 3. Those with a history of bone marrow or organ transplantation; those with coagulation dysfunction; 4. Those who suffer from immunodeficiency diseases or autoimmune diseases who are treated with immunosuppressive drugs. 5. Central nervous system (CNS) metastasis and/or cancerous meningitis; 6. Those who may be allergic to immunotherapy; 7. Drug abuse, clinical or psychological or social factors affect informed consent or research implementation; 8. Pregnant and lactating women; 9. Are participating in other clinical trials; The investigator considers uncertain factors that affect the safety or compliance of subjects.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| ORR;OS;PFS;DOR;EORTC QLQ-C30 V3.0;Immunological indicators; | — |
Primary
| Measure | Time frame |
|---|---|
| Safety Index; | — |
Countries
CHINA
Contacts
Public ContactQiang Li
Dongfang Hospital Affiliated to Tongji University; P&PMed(Shanghai)Biotechnology Co.,Led.
Outcome results
None listed