Gastric Cancer
Conditions
Interventions
Experimental group:reduced SOX+anti-PD-1
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Aged 20-75 years old; (2) The pathological diagnosis of gastric cancer or gastroesophageal junction adenocarcinoma; the cancer is diagnosed as locally unresectable; (3) The ECOG score is 0-1 points; (4) The expected survival period >=24 weeks; (5) Able to swallow pills normally; (6) untreated for any anti-tumor drugs; (7) According to the RECIST 1.1 standard, there is at least one measurable lesion, and the lesion has not been irradiated; (8) No significant organ function decline.
Exclusion criteria
Exclusion criteria: (1) The patient has clinically significant uncontrollable intestinal, cardiovascular, and respiratory diseases; (2) Have received any anti-cancer treatment; (3) Have received growth factor and GCSF drug treatment before the first administration; (4) Female patients who are pregnant or breastfeeding; (5) The patient has any active autoimmune disease or a history of autoimmune disease; (6) The patient is using immunosuppressive agents or systemic hormone therapy to achieve immunosuppressive purposes; (7) Patients who have received hematopoietic stimulating factors, such as granulocyte colony stimulating factor (G-CSF), erythropoietin, etc. within 1 week before the first administration of the study drug.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ORR;R0 resection rate;3 year OS; | — |
Secondary
| Measure | Time frame |
|---|---|
| PFS;QOL; | — |
Countries
China
Contacts
Public ContactJi Kun Li
Shanghai General Hospital
Outcome results
None listed