Liver disease
Conditions
Interventions
Experimental group:0.5 mg/kg s ketamine before operation, 0.3 mg/kg/h ketamine was continuously pumped during the operation to 30 minutes before the end of the operation
Sponsors
Hu'nan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18-60 years had ASA grade I-II and child Pugh Grade A; 2. For patients who are scheduled for hepatectomy, the porta hepatis should be blocked during the operation, and the range of hepatectomy should be at least two segments; 3. Patients who voluntarily sign ethical informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of hepatectomy; 2. Patients with massive intraoperative bleeding (total bleeding volume >= 1000ml or bleeding volume within 2min >= 400ml); The patient has difficulty in communication; 4. Patients with a history of serious cardiovascular and cerebrovascular diseases; 5. Patients with other organ dysfunction; 6. Pregnant women and patients in lactation period; 7. Patients with emergency operation; 8. In patients with arrhythmia during operation, non sinus rhythm was more than 4 times / min, lasting for more than 5 minutes; 9. Patients with endocrine diseases, chronic lung diseases and immunosuppressants; 10. Patients with a long history of taking analgesics and sedatives, taking drugs and being allergic to narcotic drugs; 11. Patients with abnormal coagulation function.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MAP;HR;recovery time;Ramsay score;VAS score;Tumor Necrosis Factor-alpha;Interleukin-6;Interleukin-10;TOA;TAC;PON-1; | — |
Countries
China
Contacts
Public ContactYuan Zhao
Hu'nan Provincial People's Hospital
Outcome results
None listed