Non-small cell lung cancer
Conditions
Interventions
control group: conventional radiotherapy GTV+CTV
treatment group 1:conventional radiotherapy GTV
treatment group 2:hypofractionated radiotherapy ( GTV: 3-4Gy×13-19F)
treatment group 3:hypofractionated radiotherapy ( GTV: 5-10Gy×5-12F)
Sponsors
Department of oncology Second Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. histologically proven non-small cell lung cancer without driver gene mutation; 2. AJCC stage IIIA-IIIC; 3. Adequate hematologic and end organ function, defined by the following laboratory results obtained within 7 days prior to randomization: Hemoglobin >= 100g/L, ANC >= 1.5*10^9/L without granulocyte colony-stimulating factor support, Platelet count >= 100*10^9/L; Serum bilirubin = 60ml/min, urea nitrogen = 70; 6. Male or female aged >= 18 years; 7. No autoimmune disease; 8. Comply with radiotherapy; 9. Signed Informed Consent Form.
Exclusion criteria
Exclusion criteria: 1. Prior radiotherapy for NSCLC; 2. Prior or current usage of CPI; 3. Malignancies other than NSCLC within 5 years prior to randomization; 4. Active infections; 5. History of congenital or acquired immunodeficiency; 6. History of autoimmune diseases; 7. History of mental disorders or mental illness can not cooperate with treatment; 8. History of serious heart, liver, lung, kidney, digestive and urinary system diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute and late radiotherapy-related toxicity;Local regional failure free survival, LRFFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Progression-Free-Survival, PFS;Overall survival, OS; | — |
Countries
China
Contacts
Public ContactGuanghui Li
Department of Oncology Second Affiliated Hospital of Army Medical University
Outcome results
None listed