Infectious diseases(MRSA),invasive fungal disease,liver transplantation
Conditions
Interventions
control group: traditional mode
Sponsors
West China hospital of sichuan university
Eligibility
Sex/Gender
All
Age
18 Years to 120 Years
Inclusion criteria
Inclusion criteria: Vancomycin, voriconazole and immunosuppressants were involved in this study 1.Vancomycin: (1) MRSA infection or highly suspected MRSA infection; (2) The patients were treated with vancomycin; (3) Serum creatinine and cystatin C were measured before vancomycin. 2. Voriconazole (1) Mycotic infection; (2) Voriconazole was proposed for treatment; (3) Liver biochemistry was measured before administration. 3. immunosuppressants (1) After liver transplantation; (2) Immunosuppressants (including one or more of tacrolimus, mycophenolate mofetil and sirolimus) were used for treatment.
Exclusion criteria
Exclusion criteria: Vancomycin, voriconazole and immunosuppressants were involved in this study 1.Vancomycin: (1) Patients younger than 18 years old; (2) Patients undergoing hemodialysis or continuous renal replacement therapy (CRRT) during vancomycin administration; (3) Patients who fasted for more than 1 week; (4) Patients with urine volume >= 4000ml / d; (5) Combined use of drugs with obvious renal toxicity (such as aminoglycoside drugs, amphotericin B). 2. Voriconazole (1) Pregnant and lactating women; (2) Patients with lower urinary tract fungal infection; (3) Combined use of drugs with obvious liver toxicity (such as isoniazid, pyrazinamide). 3. Immunosuppressive agents (1) Patients younger than 18 years old; (2) Pregnant and lactating women; (3) Patients with other organs, tissues and stem cell transplantation; (4) Patients who were treated with drugs with obvious interaction (such as rifampicin, voriconazole, HIV protease inhibitor).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the rate of trough concentrations within the desired target range;Clinical efficiency;Incidence of adverse reactions;cost; | — |
Countries
China
Contacts
Public ContactGuirong Xiao
West China Hospital of Sichuan University
Outcome results
None listed