Comparison of the effects of remazolam and midazolam on the incidence of delirium following general anesthesia in patients undergoing elective non- cardiac major surgery: a prospective randomized controlled study

Comparison of the effects of remazolam and midazolam on the incidence of delirium following general anesthesia in patients undergoing elective non- cardiac major surgery

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000037704

Enrollment

Unknown

Registered

2020-09-02

Start date

2020-09-01

Completion date

Unknown

Last updated

2020-11-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Delirium

Interventions

Mida group:Midazolam is injected intravenously before surgery

Remi group :Remazolam is injected intravenously before surgery

Eligibility

Sex/Gender

All

Age

60 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients and their legal representatives voluntarily participate in the study and sign informed consent; 2. Patients who underwent elective non cardiac surgery in our hospital, and the American Society of anesthesiologists (ASA) grade I-III; 3. The patients with age >=60 years old; 4. Patients who have not participated in clinical trials of other drugs 3 months before screening.

Exclusion criteria

Exclusion criteria: 1. Patients with other important organ dysfunction: severe liver and kidney dysfunction, brain organic disease, NYHA >=grade III, abnormal coagulation function, sick sinus syndrome, bradycardia (HR < 55 beats / min), atrioventricular block above grade II; 2. Patients with contraindications of midazolam and rimazolom; 3. Patients with serious mental disorders; 4. Patients who take sedatives or glucocorticoids for a long time; 5. Patients with history of alcohol or drug dependence; 6. Patients who were considered unsuitable for inclusion by other researchers.

Design outcomes

Primary

Measure	Time frame
POD incidence within 7 days after surgery;	—

Secondary

Measure	Time frame
The MMSE scale score within 7 days after surgery;Changes in blood pressure and heart rate during anesthesia induction;anesthesia and surgery related time;ntraoperative and postoperative adverse reactions;	—

Countries

China

Contacts

Public ContactHei Ziqing

Third Affiliated Hospital of Sun Yat-Sen University

heiziqing@sina.com+86 13925020330

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026