Asthma
Conditions
Interventions
Case series:Nil
Sponsors
Tai'an Maternal and Child Health Care Hospital
Eligibility
Sex/Gender
All
Age
5 Years to 17 Years
Inclusion criteria
Inclusion criteria: 1. Children aged 5 to 17 years; 2. Children who meet the diagnostic criteria of "guidelines for diagnosis and prevention and treatment of bronchial asthma in children (2016 Edition)" are diagnosed as mild to moderate asthma by specialists. The specific diagnostic criteria are as follows: (1) Repeated wheezing, coughing, shortness of breath and chest tightness are mostly related to exposure to allergens, cold air, physical and chemical stimulation, respiratory tract infection, exercise and hyperventilation (such as laughter and crying), which often occur or worsen in the night and (or) early morning; (2) During the attack, scattered or diffuse wheezing sounds could be heard in both lungs, mainly in the expiratory phase, and the expiratory phase was prolonged; (3) the above symptoms and signs were effective after anti asthma treatment, or relieved spontaneously; (4) Except wheezing, coughing, shortness of breath and chest tightness caused by other diseases; (5) Patients with atypical clinical manifestations (without obvious wheezing or wheezing sound) should have at least one of the following: The results showed that there was reversible airflow restriction: positive bronchodilation test: FEV1 increased by more than 12% in 15 min after inhalation of quick acting beta2 receptor agonist (such as salbutamol pressure quantitative aerosol 200-400 ug); pulmonary ventilation function improved after anti-inflammatory treatment: FEV1 increased by more than 12% after 4-8 weeks of inhaled glucocorticoids and / or anti leukotriene drugs; Bronchial provocation test was positive; The diurnal variation rate of peak expiratory flow (PEF) was more than 13%. Asthma can be diagnosed if they meet the requirements of 1 ~ 4 or 4,5; 3. Patients with well controlled asthma; 4. Oral consent of the child, informed consent of the parents or legal guardian of the child, and can fill in the questionnaire truthfully.
Exclusion criteria
Exclusion criteria: 1. Children with other chronic lung diseases, such as bronchiectasis, cystic fibrosis, interstitial lung disease, pneumonia, etc; 2. Wheezing children caused by other reasons (such as bronchopulmonary dysplasia, primary ciliary dyskinesia, congenital respiratory tract malformation, mechanical obstruction, heart disease, neuromuscular abnormality, etc.) or combined with primary immunodeficiency disease; 3. Children with serious primary diseases of heart, liver, kidney, hematopoietic system and other organs; 4. Children with severe asthma; 5. FeNO was measured in children who ate spinach, animal viscera and other foods with high nitrogen content. Coffee, cola and other stimulant drinks were consumed 2 hours before the test, and those who exercised strenuously 4 hours before were measured; 6. Children who used ICs, short acting bronchodilator or both 6 hours before IOS test; 7. Children with acute asthma attack requiring systemic glucocorticoid treatment within 4 weeks before inclusion; 8. Patients who have participated in other clinical studies within 30 days; 9. Other situations in which the researcher considers it inappropriate to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulse oscillation lung function;spirometry;Chitinase protein-40; | — |
Countries
China
Contacts
Public ContactLiu Gangtie
Tai'an Maternal and Child Health Care Hospital
Outcome results
None listed