pneumonia
Conditions
Interventions
severe pneumonia, mild pneumonia and healthy controls :collect the blood
Sponsors
Huashan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Severe pneumonia: 1. Patients with newly developed cough, expectoration, or aggravation of original respiratory diseases, and purulent sputum with or without chest pain; 2. Patients with fever; 3. Patients with pulmonary consolidation signs or moist rales; 4. WBC > 10 * 10^9 / L or 7 mmol / L, 1 point; respiratory rate >= 30 times / min, 1 point; systolic blood pressure = 65 years old, 1 point; curb 65 >= 3 points, diagnosed as severe pneumonia. Mild pneumonia: 1. Patients with newly developed cough, expectoration, or aggravation of original respiratory diseases, and purulent sputum with or without chest pain; 2. Patients with fever; 3. Patients with pulmonary consolidation signs or moist rales; 4. WBC > 10 * 10^9 / L or < 4 * 10^9 / L, with or without nuclear left shift; 5. Chest X-ray examination showed patchy, infiltrative shadow or interstitial changes, patients with or without pleural effusion, or showed new inflammatory lesions compared with the previous X-ray films; 6. Patients with the same pathogen isolated from BALF or deep sputum for two consecutive times, or proved by immunological methods, or with histopathological evidence and imaging findings; 7. Clinical diagnosis can be established for patients who meet any one of 1-5 plus item 6, and exclude lung tumor, interstitial lung disease, pulmonary edema, atelectasis, pulmonary embolism, pulmonary eosinophilic infiltration, pulmonary vasculitis, etc. 8. Patients with mild pneumonia were diagnosed with curb 65 score of 0-2. Healthy control (HC): the inclusion criteria were no clinical manifestations and imaging evidence of pulmonary infection, no previous immunosuppressive disease, no diabetes mellitus, and no use history of immunosuppressive agents in the past 6 months.
Exclusion criteria
Exclusion criteria: 1. Patients younger than 18 years old and over 80 years old; 2. Patients with severe coagulation or hemolysis in the sample; 3. Incorrect sample collection or storage objects; 4. The sample did not complete the evaluation according to the plan.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Immune markers; | — |
Countries
China
Contacts
Public ContactGao Yan
Huashan Hospital Affiliated to Fudan University
Outcome results
None listed