spontaneous preterm birth
Conditions
Interventions
experimental group :vaginal progesterone
control group:no vaginal progesterone
Sponsors
Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. singleton pregnancy; 2. with a history of ervical excision; 3. visiting our research center before 8 gestational week; 4. signing the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with fetal malformation; 2. Patients with iatrogenic premature delivery; 3. The objects related to infection identified in the previous pregnancy loss; 4. Patients with congenital uterine malformation or myoma >= 5 cm or multiple myoma; 5. Subjects with chronic diseases (such as renal insufficiency, type I diabetes, some autoimmune diseases, etc.); 6. Patients with infectious diseases; 7. Patients with mental illness, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| rate of preterm birth < 34 weeks; | — |
Secondary
| Measure | Time frame |
|---|---|
| rate of preterm birth < 28 weeks;neonatal birth weight;five minute Apgar score;NICU admission rate;neonatal IVH;neonatal ROP;neonatal PDA;neonatal BPD;NRDS;mechanical ventilation;neonatal NEC;estational week of delivery;rate of preterm birth < 37 weeks;rate of preterm birth < 32weeks;rate of preterm birth < 30 weeks;neonatal sepsis;Composite neonatal morbidity/mortality;neonatal mortality; | — |
Countries
China
Contacts
Public ContactYing Hao
Department of Obstetrics, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine
Outcome results
None listed