Lung Cancer
Conditions
Interventions
topical therapy group:Inhalation budesonide 2mg 3 times per day
systemic glucocorticoid therapy group:intravenous methylprednisolone 1~2mg/kg
Sponsors
Shanghai Pulmonary Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years; 2. ECOG score 0-3; 3. Histologically or cytologically confirmed lung cancer,including non-small cell lung cancer and small cell lung cancer; 4. Recieving anti-PD-1/PD-L1 therapy; 5. Grade 2 of ICI-related penumonitis occured; 6. Patients must join the study voluntarily.They should be cooperate with examination,treatment and follow-up.
Exclusion criteria
Exclusion criteria: 1. Have recieved systemic glucocorticoid treatment; 2. Allergic to adrenocorticosteroids; 3. Existed contraindication of glucocorticoid treatment, estimate by researchers; 4. Medical history, disease, treatment or abnormal laboratory results that may interfere with the results and prevent patients from participating in this study. Or the researchers think that it is not in the best interests of patients to participate in this study; 5. The investigators believe that it is not suitable for inclusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| treatment response rate;immunotherapy suspended time; | — |
Secondary
| Measure | Time frame |
|---|---|
| time to recover;immunotherapy re-challenge rate; | — |
Countries
China
Contacts
Public ContactJing Zhao
Shanghai Pulmonary Hospital
Outcome results
None listed