Rosacea
Conditions
Interventions
Carvedilol group:Oral carvedilol 5mg bid
minocycline group:Oral minocycline 100mg qd
Sponsors
The First Affiliated Hospital of Army Medical University (Southwest Hospital)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged >=18 years old; 2. have been diagnosed of ETR with significant facial flushing and erythema but without papulopustular lesions; 3. clinicians Erythema Assessment (CEA) (Table 1) scores >= 2.
Exclusion criteria
Exclusion criteria: 1) Patients who were allergic to carvedilol or minocycline hydrochloride; 2) Patients with bronchial asthma; 3) Patients with hypotension or bradycardia detected by blood pressure monitoring and electrocardiogram; 4) Patients with severe cardiovascular diseases, orthostatic hypotension, cerebral or coronary insufficiency; 5) Patients with severe systemic diseases (myocardial infarction, cardiac failure, cerebral infarction, liver cancer, liver cirrhosis, renal syndrome, acute/chronic renal failure) and hematopoietic disease; 6) Patients with acne, ectopic dermatitis and other facial skin diseases; 7) Pregnant or nursing women and those who plan to become pregnant within one year; 8) Patients who have current drugs, tobacco and alcohol addiction; 9) Patients with malignant tumors, systemic failure or immunodeficiency; 10) Patients who have previously used oral isotretinoin, antibiotics, steroids and other immune suppressants, systemic photochemotherapy, or the use of vasodilators or a-adrenergic receptor-blocking agents in the previous 4 weeks; 11) Patient that have been through topical or laser therapy for rosacea in the previous 4 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinician’s Erythema Assessment (CEA);Patient’s Self-Assessment (PSA); | — |
Secondary
| Measure | Time frame |
|---|---|
| The rosacea-specific Qol instrument (RosaQoL);Patient health questionnaire-9 (PHQ-9);Generalized anxiety disorder (GAD-7);Symptom Assessment Form (SAF); | — |
Countries
China
Contacts
Public ContactLi Jian
The First Affiliated Hospital of Army Medical University (Southwest Hospital)
Outcome results
None listed