narcotic analgesic
Conditions
Interventions
grouped according to whether they carried CYP3A4 * 1 and CYP3A5 * 3:Nil
Sponsors
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients undergoing elective general anesthesia downlink lumbar surgery, the han nationality, aged 18 to 65 years old, ASA I ~ III level, body mass index (BMI) of 18 to 25, line need PCA postoperative analgesia.
Exclusion criteria
Exclusion criteria: Severe systemic diseases such as heart, brain, liver and kidney; A history of mental and neurological diseases was determined before operation.A long history of smoking and alcohol abuse; A history of long-term use of valium or opioids;Liver CYP3A inducer or inhibitor was taken within 1 month before surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The total amount of sufentanil used intraoperatively;The total amount of sufentanil used in the first 24 h controlled analgesia pump in each group after surgery;Mean visual analogue scale within 24h after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Occurrence of postoperative analgesia adverse reactions; | — |
Countries
China
Contacts
Public ContactDing Lingling
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University
Outcome results
None listed